PIMA547989
TCR V alpha 11 Chimeric Recombinant Mouse Monoclonal Antibody (34), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547989-Each-of-1 | In Stock | ₹ 46,769.50 |
PIMA547989 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
TCR V alpha 11 Chimeric
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% ProClin 300
Gene Accession No.
P01854
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3497
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1 κ
Applications
ELISA, Flow Cytometry, Western Blot
Clone
34
Conjugate
Unconjugated
Gene
IGHE
Gene Alias
TCR V alpha11; TCRV alpha 11; TCRV alpha11; Va11; Valpha11
Immunogen
Purified recombinant soluble TCR from the T-cell hybridoma 85.33, corresponding to V alpha 11.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- Specificity: This antibody binds to the T-cell receptor alpha chains
- The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response
- TCR recognition of self-peptides has been linked to autoimmune disease
- Mutant self-peptides have been associated with tumors
- Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome
- Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)
- The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease
- Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP)
- A small number of T cells lack both CD4 and CD8 (double negative, DN)
- Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders
- Gamma-delta T cells are primarily found within the epithelium
- They show less TCR diversity and recognize antigens differently than alpha-beta T cells
- Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.