Apolipoprotein B Monoclonal Antibody (F2C4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMIA1606-Each-of-1 | In Stock | ₹ 67,773.50 |
PIMIA1606 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 67,773.50
GST (18%): ₹ 12,199.23
Total Price: ₹ 79,972.73
Antigen
Apolipoprotein B
Classification
Monoclonal
Concentration
5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
P04114
Gene Symbols
APOB
Immunogen
Purified human serum LDL
Quantity
1 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
ELISA, Immunocytochemistry, Immunoprecipitation, Radioimmune Assays (RIA)
Clone
F2C4
Conjugate
Unconjugated
Gene
APOB
Gene Alias
Aa1064; Ac1-060; AI315052; Apo B100; Apo B-100; Apo B-48; APOB; apo-B; ApoB 100; ApoB 48; ApoB-100; apob-48; apolipo b; apolipoprotein B; apolipoprotein B (including Ag(x) antigen); Apolipoprotein B 100; Apolipoprotein B 48; apolipoprotein B PI; Apolipoprotein B100; apolipoprotein B-100; apolipoprotein B46; apolipoprotein B47; apolipoprotein B48; Apolipoprotein B-48; apolipoprotein B49; FLDB; LDLCQ4; LOX-1; mCG_129875; MGC176318; Ox-LDL receptor 1
Host Species
Mouse
Purification Method
Ion-exchange chromatography
Regulatory Status
RUO
Gene ID (Entrez)
338
Content And Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Form
Liquid
Related Products
Description
- MIA1606 targets Apolipoprotein B in ELISA, IP, and RIA applications and shows reactivity with Human samples
- The MIA1606 immunogen is purified human serum LDL
- MIA1606 detects Apolipoprotein B which has a predicted molecular weight of approximately 513 kDa
- MIA1606 was formerly sold as a Seradyn product
- Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa
- Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation
- Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood
- LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearance of cholesterol from the circulation
- In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36
- Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described
- MDA-oxidized LDL appear to be different from LDL oxidized by other means
- Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a)
- Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis
- Normal plasma apolipoprotein B levels are around 800mg/L
- Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100
- The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA
- The two isoforms share a common N-terminal sequence
- The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination
- Mutations in the Apolipoprotein B gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective Apolipoprotein B, diseases affecting plasma cholesterol and Apolipoprotein B levels.