Cyclophilin B Polyclonal Antibody, Alexa Fluor™ 488, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA1027A48-Each-of-1 | In Stock | ₹ 39,961.00 |
PIPA1027A48 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,961.00
GST (18%): ₹ 7,192.98
Total Price: ₹ 47,153.98
Antigen
Cyclophilin B
Classification
Polyclonal
Conjugate
Alexa Fluor 488
Gene
PPIB
Gene Alias
AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19035, 478337, 5479, 64367
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Immunocytochemistry
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.
P23284, P24368, P24369
Gene Symbols
PPIB
Immunogen
Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB
Quantity
50 μL
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1027AA488 detects cyclophilin B (CyPB) in mouse, rat, canine, and human tissues
- The PA1027AA488 immunogen is a synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB
- This sequence is almost completely conserved between human, mouse, rat, bovine, and chicken
- PA1027AA488 immunizing peptide (Cat
- # PEP-058) is available for use in neutralization and control experiments
- Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506
- Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP)
- Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation
- Thus, providing a possible mechanism of immunosuppression by CsA and FK506
- Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds
- As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.