PIPA125150
NPHP1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA125150-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA125150 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
NPHP1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NPHP1
Gene Alias
JBTS4; juvenile nephronophthisis 1 protein; nephrocystin 1; Nephrocystin1; nephrocystin-1; nephronophthisis 1 (juvenile); nephronophthisis 1 (juvenile) homolog; nephronophthisis 1 (juvenile) homolog (human); NPH1; NPHP1; SLSN1
Host Species
Rabbit
Purification Method
IgG fraction
Regulatory Status
RUO
Gene ID (Entrez)
53885
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q9QY53
Gene Symbols
NPHP1
Immunogen
Fusion protein corresponding to the pic region (residues 612-691) of mouse NPH.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Juvenile nephronophthisis type 1 is caused by mutations of NPHP1, the gene encoding for nephrocystin
- Nephrocystin interacts with p130Cas (BCAR1), proline-rich tyrosine kinase-2 (PTK2B or Pyk2), and tensin in embryonic kidney and testis, indicating that these proteins participate in a common signaling pathway
- Nephrocystin and p130Cas interact in mammalian cells and both proteins prominently localize at or near sites of cell-cell contact in polarized Madin-Darby canine kidney epithelial cells
- Expression of nephrocystin results in phosphorylation of Pyk2 on Tyrosine 402 as well as activation of downstream mitogen-activated protein kinases, such as ERK1 and ERK2
- Nephrocystin contains a src-homology 3 (SH3) domain, which is highly conserved throughout evolution.