PEDF Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA129882-Each-of-1 | In Stock | ₹ 49,439.50 |
PIPA129882 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
PEDF
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SERPINF1
Gene Alias
AI195227; alpha-2 antiplasmin; caspin; Cell proliferation-inducing gene 35 protein; Dmrs91; EPC 1; EPC1; EPC-1; OI12; OI6; PEDF; Pedfl; PIG 35; PIG35; pigment epithelium derived factor; pigment epithelium-derived factor; Sdf3; SDF-3; serine (or cysteine) peptidase inhibitor, clade F, member 1; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; serpin F1; serpin family F member 1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serpin peptidase inhibitor, clade F, member 1; SERPINF 1; Serpinf1; serpin-F1; sserpin family F member 1; stromal cell derived factor 3; stromal cell-derived factor 3; testis tissue sperm-binding protein Li 70n
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
20317, 287526, 5176
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
0.1M tris glycine with 0.15M NaCl, 30% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P36955, P97298
Gene Symbols
SERPINF1
Immunogen
His tagged fusion protein corresponding to full length human PEDF (Pigment Epithelial Derived Factor) expressed in baby hamster kidney cells.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: RIPA lysates from Y79 cells
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties
- It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body
- A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells
- In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2
- The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins
- The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin
- To date, PEDF-R is the only signaling receptor known to be used by a serpin family member
- The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR)
- PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.