ErbB3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA131989-Each-of-1 | In Stock | ₹ 61,143.00 |
PIPA131989 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 61,143.00
GST (18%): ₹ 11,005.74
Total Price: ₹ 72,148.74
Antigen
ErbB3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ERBB3
Gene Alias
avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; C76256; c-erbB3; c-erbB-3; C-errB-3; erb-b2 receptor tyrosine kinase 3; ERBB3; Erbb-3; Erbb3r; erbB3-S; glial growth factor receptor; HER3; human epidermal growth factor receptor 3; LCCS2; MDA BF 1; MDA-BF-1; MGC88033; nuc-ErbB3; p180 ErbB3; p180-ErbB3; p45 sErbB3; p45-sErbB3; p85 sErbB3; p85-sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; receptor tyrosine-protein kinase erbB-3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Host Species
Rabbit
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
13867, 2065
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.3 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P21860, Q61526
Gene Symbols
ERBB3
Immunogen
KLH conjugated synthetic peptide between 24-55 amino acids from the N-terminal region of human ERBB3.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Western blot detects a band of ∽148 kDa, and has a predicted molecular weight of 161 kDa
- Mouse brain lysate can be used as a positive control
- ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family
- ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon
- Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents
- The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6
- 2kb mRNA which is translated into a 160/180 kDa glycoprotein
- The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity
- Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation
- Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized
- One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form
- Additional splice variants have also been reported, but they have not been thoroughly characterized.