IFI16 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102546-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102546 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
IFI16
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IFI16
Gene Alias
gamma-interferon-inducible protein 16; IFI 16C; IFI16; Ifi-16; IFNGIP1; interferon gamma inducible protein 16; interferon, gamma-inducible protein 16; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator; PYHIN2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3428
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q16666
Gene Symbols
IFI16
Immunogen
A synthesized peptide derived from human IFI16(Accession Q16666), corresponding to amino acid residues E739-F785.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total IFI16
- IFI16 (gamma-inteferon-inducible protein 16) binds double-stranded DNA
- It binds preferentially to supercoiled DNA and cruciform DNA structures
- It seems to be involved in transcriptional regulation and as a transcriptional repressor
- IFI16 may have a role in the regulation of hematopoietic differentiation through activation of unknown target genes
- It controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein
- IFI16 is also involved in innate immune response by recognizing viral dsDNA in the cytosol and nucleus
- After binding to viral DNA in the cytoplasm, IFI16 recruits TMEM173/STING and mediates the induction of IFN-beta
- It is necessary to activate the IFR3 signaling cascade suring human herpes simplex virus 1 infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibiton of viral immediate-early gene expression and replication
- IFI16 is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.