PIPA5102991
ING4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102991-Each-of-1 | In Stock | ₹ 41,607.50 |
PIPA5102991 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,607.50
GST (18%): ₹ 7,489.35
Total Price: ₹ 49,096.85
Antigen
ING4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ING4
Gene Alias
brain my036 protein; candidate tumor suppressor p33 ING1 homolog; D6Wsu147e; D6Xrf92; ING1-like protein; Ing4; inhibitor of growth family member 4; inhibitor of growth family, member 4; inhibitor of growth protein 4; My036; p29ING4
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51147
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9UNL4
Gene Symbols
ING4
Immunogen
A synthesized peptide derived from human ING4(Accession Q9UNL4), corresponding to amino acid residues S123-M173.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total ING4
- The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors
- All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure
- ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence
- The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis
- Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors
- ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes
- Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.