RAD18 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102756-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5102756 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
RAD18
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Rad18
Gene Alias
2810024C04Rik; E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; mRAD18Sc; postreplication repair protein hRAD18p; postreplication repair protein RAD18; post-replication repair protein RAD18SC; Rad18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); RAD18, E3 ubiquitin protein ligase; RAD18, S. cerevisiae, homolog; Rad18sc; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18; RNF73
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
362412, 56852, 58186
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9NS91, Q9QXK2
Gene Symbols
Rad18
Immunogen
A synthesized peptide derived from human RAD18(Accession Q9NS91), corresponding to amino acid residues N306-Q356.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total RAD18
- Human Rad18 (hRad18) is homologue of the S
- pombe Rad18 (3,4)
- In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2)
- Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast
- In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4)
- It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18
- This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1)
- The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers
- The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa
- The human Rad18 is ubiquitously expressed in various human tissues.