MDMX Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102843-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102843 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MDMX
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM4
Gene Alias
4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; DKFZp781B1423; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX; human homolog of; Mdm2-like p53-binding protein; MDM4; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; MDM4-related protein 1; Mdmx; MGC132766; MRP1; p53-binding protein Mdm4; Protein Mdm4; protein Mdmx; RP11-430C7.1; transformed mouse 3T3 cell double minute 4
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17248, 304798, 4194
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O15151, O35618, Q5XIN1
Gene Symbols
MDM4
Immunogen
A synthesized peptide derived from human MDM4(Accession O15151), corresponding to amino acid residues T343-E393.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total MDM4
- The MDM2 protein is the primary regulator of p53 protein stability
- MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2
- The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas
- ARF interacts with MDMX to sequester MDMX within the nucleolus
- This sequestration of MDMX by ARF results in an increase in p53 transactivation
- In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation
- Like MDM2, MDMX also binds p73 and stabilizes the level of p73
- Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.