Phospho-Doublecortin (Ser335) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102854-Each-of-1 | In Stock | ₹ 41,607.50 |
PIPA5102854 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,607.50
GST (18%): ₹ 7,489.35
Total Price: ₹ 49,096.85
Antigen
Phospho-Doublecortin (Ser335)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DCX
Gene Alias
DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13193, 1641, 84394
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O43602, O88809, Q9ESI7
Gene Symbols
DCX
Immunogen
A synthesized peptide derived from human DCX(Accession O43602), corresponding to amino acid residues around phosphorylated Ser335.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of Doublecortin only when phosphorylated at Ser335
- In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation
- DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules
- It contains two doublecortin domains, which bind microtubules
- In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex
- Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.