eIF3b Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103095-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103095 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
eIF3b
Classification
Polyclonal
Conjugate
Unconjugated
Gene
EIF3B
Gene Alias
AL033316; AL033334; AL033369; AW208965; D5Wsu45e; eIF3 p110; eIF3 p116; EIF3B; eIF3b {ECO:0000255; eIF-3-eta; EIF3-ETA; eIF-3-eta {ECO:0000255; EIF3-P110; EIF3-P116; EIF3S9; eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255; Eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3 subunit B {ECO:0000255; eukaryotic translation initiation factor 3, subunit 9 (eta); eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; eukaryotic translation initiation factor 3, subunit B; HAMAP-Rule:MF_03001}; hPrt1; MGC104664; MGC131875; PRT1; Prt1 homolog
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27979, 8662
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P55884, Q8JZQ9
Gene Symbols
EIF3B
Immunogen
A synthesized peptide derived from human EIF3B(Accession P55884), corresponding to amino acid residues A128-Q178.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total EIF3B
- RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815)
- The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC)
- The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition
- The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632)
- The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
- [UniProt]