DIO3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103127-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103127 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DIO3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DIO3
Gene Alias
5DIII; D3; deiodinase, iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; Dio3; DIOIII; I79_015795; iodothyronine deiodinase 3; iodothyronine deiodinase, placental type; Itdi3; LOW QUALITY PROTEIN: thyroxine 5-deiodinase; thyroxine 5-deiodinase; thyroxine deiodinase; thyroxine deiodinase type III (selenoprotein); TXDI3; Type 3 DI; type 3 iodothyronine selenodeiodinase; type III iodothyronine deiodinase; type-III 5' deiodinase; type-III 5'-deiodinase
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
107585, 1735, 29475
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P49897, P55073, Q91ZI8
Gene Symbols
DIO3
Immunogen
A synthesized peptide derived from human DIO3(Accession P55073), corresponding to amino acid residues V117-V141.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total DIO3
- DIO3 belongs to the iodothyronine deiodinase family
- It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively
- This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development
- This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity
- The selenocysteine is encoded by the UGA codon, which normally signals translation termination
- The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.