Phospho-MEKK1 (Thr1400) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103271-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5103271 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
Phospho-MEKK1 (Thr1400)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP3K1
Gene Alias
MAP/ERK kinase kinase 1; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; si:rp71-80a19.2; SRXY6
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
116667, 26401, 4214
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P53349, Q13233, Q62925
Gene Symbols
MAP3K1
Immunogen
A synthesized peptide derived from human MAP3K1(Accession Q13233), corresponding to amino acid residues around phosphorylated Thr1400.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of MEKK1 only when phosphorylated at Thr1400, which site historically referenced as Thr1402
- Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK)
- MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK
- The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells
- MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases
- It is also a highly efficient activator of the JNK cascade
- The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.