GEMIN8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103503-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103503 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
GEMIN8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GEMIN8
Gene Alias
B130034M20Rik; B930082C09Rik; BC023488; Fam51a1; family with sequence similarity 51, member A1; family with sequence similarity 51, member A1 homolog; gem (nuclear organelle) associated protein 8; gem nuclear organelle associated protein 8; gem-associated protein 8; GEMIN8; Gemin-8; Protein FAM51A1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
237221, 363462, 54960
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q8BHE1, Q9NWZ8
Gene Symbols
GEMIN8
Immunogen
A synthesized peptide derived from human GEMIN8(Accession Q9NWZ8), corresponding to amino acid residues R203-F242.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total GEMIN8
- The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome
- Thereby, plays an important role in the splicing of cellular pre-mRNAs
- Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP
- In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP
- Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.