TNIP3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103506-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103506 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
TNIP3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TNIP3
Gene Alias
9030611K07Rik; A20-binding inhibitor of NF-kappa-B activation 3; ABIN3; ABIN-3; ABIN-3 beta; LIND; Listeria induced; listeria-induced gene protein; TNFAIP3 interacting protein 3; TNFAIP3-interacting protein 3; TNFAIP3-interacting protein 3 beta; Tnip3; TNIP3 beta
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
414084, 79931
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q96KP6
Gene Symbols
TNIP3
Immunogen
A synthesized peptide derived from human TNIP3(Accession Q96KP6), corresponding to amino acid residues T77-L127.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total TNIP3
- The nuclear factor NF-kappa-B plays key roles in development and immunity
- ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappa-B activation
- ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS
- ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow
- Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kappa-B inhibition is mediated by the ABIN-homology domain 2
- ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone
- Enhanced expression of ABIN3 in monocytes is associated with sepsis
- Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappa-B in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions
- At least four isoforms of ABIN3 are known to exist.