Agrin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103585-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA5103585 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
Agrin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Agrn
Gene Alias
AGR; Agrin; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 22 kDa fragment; Agrin C-terminal 90 kDa fragment; Agrin N-terminal 110 kDa subunit; agrin proteoglycan; Agrn; C22; C90; CMS8; CMSPPD; nmf380; RP23-139J18.2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11603, 25592, 375790
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
A2ASQ1, O00468, P25304
Gene Symbols
Agrn
Immunogen
A synthesized peptide derived from human AGRN(Accession O00468), corresponding to amino acid residues V1978-P2028.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total AGRN
- Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation
- Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction
- Several Agrin variants have been identified which arise from alternative mRNA splicings
- Agrin splice forms having inserts at two sites in the carboxy terminus designated "ey"e and "ez"e display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly
- Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention
- Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation
- Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.