UNC5A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103957-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5103957 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
UNC5A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Unc5a
Gene Alias
Kiaa1976; mKIAA1976; netrin receptor UNC5A; netrin receptor Unc5h1; protein unc-5 homolog 1; Protein unc-5 homolog A; transmembrane receptor Unc5H1; unc5 (C.elegans homolog) a; unc5 homolog 1; unc-5 homolog 1; unc-5 homolog A; unc-5 homolog A (C. elegans); unc-5 netrin receptor A; UNC5A; Unc5h1; UNC5H1FLJ16449
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
107448, 60629, 90249
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O08721, Q6ZN44, Q8K1S4
Gene Symbols
Unc5a
Immunogen
A synthesized peptide derived from human UNC5A(Accession Q6ZN44), corresponding to amino acid residues S356-G406.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total UNC5A
- The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells
- Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain, UNC5H receptors induce apoptosis
- This activity is blocked by the binding of netrin-1
- In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity
- The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers
- UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane
- Three isoforms of UNC5H1 exist due to alternative splicing events.