Phospho-IGF1R (Tyr1161) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104774-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA5104774 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
Phospho-IGF1R (Tyr1161)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IGF1R
Gene Alias
A330103N21Rik; CD221; CD221 antigen; D930020L01; hyft; IGF 1 receptor; IGF 1R; IGF1R; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16001, 25718, 3480
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P08069, P24062, Q60751
Gene Symbols
IGF1R
Immunogen
A synthesized peptide derived from human IGF1R(Accession P08069), corresponding to amino acid residues around phosphorylated Tyr1161.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of IGF1R/Insulin Receptor only when phosphorylated at Tyrosine 1161
- IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2
- IGFR has been implicated in a variety of cancers
- The protein is a tetramer consisting of two alpha, and two beta subunits
- The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2
- Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136
- The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.