Phospho-Cyclin B1 (Ser147) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104796-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104796 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-Cyclin B1 (Ser147)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ccnb1
Gene Alias
Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25203, 268697, 891
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P14635, P24860, P30277
Gene Symbols
Ccnb1
Immunogen
A synthesized peptide derived from human CCNB1(Accession P14635), corresponding to amino acid residues around phosphorylated Ser147.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of Cyclin B1 only when phosphorylated at Serine 147
- Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs)
- Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis
- It is essential for the control of the cell cycle at the G2/M transition
- Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF)
- Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase
- Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis
- Destruction of Cyclin B1 is required for cell cycle progression
- Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.