Phospho-PTP1B (Ser50) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104825-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-PTP1B (Ser50)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PTPN1
Gene Alias
CPTP1; EC 3.1.3.48; EGK_02300; hgnc9642; KIAA0283; protein tyrosine phosphatase 1B; protein tyrosine phosphatase non-receptor type 1; protein tyrosine phosphatase, non-receptor type 1; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; Ptp; PTP1B; PTP-1B; ptp1b protein; PTP-HA2; Ptpn1; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1; wu:fk54h03
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19246, 24697, 5770
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P18031, P20417, P35821
Gene Symbols
PTPN1
Immunogen
A synthesized peptide derived from human PTPN1(Accession P18031), corresponding to amino acid residues around phosphorylated Ser50.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of PTP1B only when phosphorylated at Serine 50
- PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response
- It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK
- PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades
- It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion
- PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.