Phospho-MEK3 (Ser189) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104912-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104912 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-MEK3 (Ser189)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP2K3
Gene Alias
AW212142, dual specificity mitogen-activated protein kinase kinase 3, EC 2.7.12.2, MAP kinase kinase 3, Map2k3, MAPK/ERK kinase 3, MAPKK 3, MAPKK3, MEK 3, Mek3, mitogen activated protein kinase kinase 3, mitogen-activated protein kinase kinase 3, Mkk3, mMKK3b, Prkmk3, protein kinase, mitogen-activated, kinase 3, SAPK kinase 2, SAPKK2, SAPKK-2, SKK2, Stress-activated protein kinase kinase 2
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
26397, 303200, 5606
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O09110, P46734
Gene Symbols
MAP2K3
Immunogen
A synthesized peptide derived from human MAP2K3(Accession P46734), corresponding to amino acid residues around phosphorylated Ser189.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of MKK3 only when phosphorylated at Serine 189
- MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter
- It phosphorylates and thus activates MAPK14/p38-MAPK
- This kinase can be activated by insulin, and is necessary for the expression of glucose transporter
- Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells
- The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis
- Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MEK3.