Phospho-ITCH / AIP4 (Tyr420) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105078-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105078 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-ITCH / AIP4 (Tyr420)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ITCH
Gene Alias
6720481N21Rik; 8030492O04Rik; A130065M08; ADMFD; AIF4; AIP4; atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; C230047C07Rik; dJ468O1.1; E3 ubiquitin-protein ligase Itchy; E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; ITCH; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase; itchy E3 ubiquitin protein ligase homolog; itchy, E3 ubiquitin protein ligase; NAPP1; NFE2-associated polypeptide 1
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16396, 83737
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q8C863, Q96J02
Gene Symbols
ITCH
Immunogen
A synthesized peptide derived from human ITCH(Accession Q96J02), corresponding to amino acid residues around phosphorylated Tyr420.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of ITCH only when phosphorylated at Tyr420
- Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy
- The protein encoded by this gene interacts with atrophin-1
- This encoded protein is a closely related member of the NEDD4-like protein family
- This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes
- This encoded protein contains four tandem WW domains and a HECT domain
- It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling
- It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.