Phospho-RAD18 (Ser403) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105235-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105235 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-RAD18 (Ser403)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Rad18
Gene Alias
2810024C04Rik; E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; mRAD18Sc; postreplication repair protein hRAD18p; postreplication repair protein RAD18; post-replication repair protein RAD18SC; Rad18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); RAD18, E3 ubiquitin protein ligase; RAD18, S. cerevisiae, homolog; Rad18sc; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18; RNF73
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
56852, 58186
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9NS91, Q9QXK2
Gene Symbols
Rad18
Immunogen
A synthesized peptide derived from human RAD18(Accession Q9NS91), corresponding to amino acid residues around phosphorylated Ser403.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of RAD18 only when phosphorylated at Ser403
- Human Rad18 (hRad18) is homologue of the S
- pombe Rad18 (3,4)
- In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2)
- Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast
- In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4)
- It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18
- This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1)
- The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers
- The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa
- The human Rad18 is ubiquitously expressed in various human tissues.