OTUD7B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5106333-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5106333 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
OTUD7B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
OTUD7B
Gene Alias
2900060B22Rik; 4930463P07Rik; AI462125; cellular zinc finger anti-NF-kappaB Cezanne; cellular zinc finger anti-NF-kappa-B protein; CEZANNE; OTU deubiquitinase 7B; OTU domain containing 7B; OTU domain-containing protein 7B; OTUD7B; RGD1308111; Trabid2; TRAF binding domain containing 2; Za20d1; Zinc finger A20 domain-containing protein 1; zinc finger protein Cezanne; zinc finger, A20 domain containing 1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
229603, 310677, 56957
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
B2RUR8, Q6GQQ9
Gene Symbols
OTUD7B
Immunogen
A synthesized peptide derived from human OTUD7B(Accession Q6GQQ9), corresponding to amino acid residues D757-C807.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total OTUD7B
- Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses
- In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B
- Negatively regulates mucosal immunity against infections
- Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241)
- Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2
- Mediates deubiquitination of EGFR (PubMed:22179831)
- Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584)
- Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584)
- Hydrolyzes both linear and branched forms of polyubiquitin
- [UniProt]