WASF3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5110576-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5110576 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
WASF3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
WASF3
Gene Alias
Brush-1; KIAA0900; Protein WAVE-3; SCAR3; Verprolin homology domain-containing protein 3; WAS protein family member 3; WAS protein family, member 3; Wasf3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; WAVE3; Wiskott-Aldrich syndrome protein family member 3
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10810, 245880, 682937
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.71 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q8VHI6, Q9UPY6
Gene Symbols
WASF3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human WASF3 (NP_001278894.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: RTRKEEWERR KMGIEFMSDA KKLEQAGSAK EDRVPSGSHA SDVTDYSYPA TPNHSLHPQP VTPSYAAGDV PPHGPASQAA EHEYRPPSAS ARHMALNRPQ Q WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization
- The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton
- The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases
- The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac
- The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments
- WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes
- WAVE3 forms a multiprotein complex that links receptor kinases and actin
- Binding to actin occurs through a C-terminal verprolin homology domain in all family members
- The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.