NEK8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111124-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111124 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
NEK8
Classification
Polyclonal
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q86SG6
Gene Symbols
NEK8
Immunogen
Recombinant Protein corresonding to Human NEK8
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry
Conjugate
Unconjugated
Gene
NEK8
Gene Alias
4632401F23Rik; b2b1449Clo; JCK; juvenile cystic kidney; NEK 8; NEK12A; Nek8; nephrocystin 9; never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; NIMA (never in mitosis gene a)-related expressed kinase 8; NIMA related kinase 8; NIMA-family kinase NEK8; NIMA-related expressed kinase 8; NIMA-related kinase 12a; NIMA-related kinase 8; nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9; RHPD2; Serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
284086
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Immunogen sequence: QPQPQFISRF LEGQSGVTIK HVACGDFFTA CLTDRGIIMT FGSGSNGCLG HGSLTDISQP TIVEALLGYE MVQVA NEK8 serine/threonine kinase or NIMA-related kinase 8 is related to NIMA (never in mitosis, gene A) of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase
- NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development
- NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins
- Required for renal tubular integrity
- May regulate local cytoskeletal structure in kidney tubule epithelial cells
- May regulate ciliary biogenesis through targeting of proteins to the cilia.Defects in NEK8 are the cause of nephronophthisis type 9 (NPHP9) [MIM:613824]
- NPHP9 is an autosomal recessive disorder resulting in end-stage renal disease
- It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.