TRPM4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5111134-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA5111134 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
TRPM4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TRPM4
Gene Alias
1110030C19Rik; AW047689; Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4; LTrpC4; LTrpC-4; melastatin like 2 protein; melastatin-4; Melastatin-like 2; MLS2s; PFHB1B; transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential ion channel melastatin subgroup member 4; Trpm4; TRPM4B
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
54795
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.8 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q8TD43
Gene Symbols
TRPM4
Immunogen
Recombinant Protein corresonding to Human TRPM4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: GTGIDIPVLL LLIDGDEKML TRIENATQAQ LPCLLVAGSG GAADCLAETL EDTLAPGSGG ARQGEARDRI RRFFPKGDLE VLQAQVERIM TRKE Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization
- While it is activated by increase in intracellular Ca2+, it is impermeable to it
- Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane
- It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc
- Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production
- Involved in myogenic constriction of cerebral arteries
- Controls insulin secretion in pancreatic beta-cells
- May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload
- Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization
- Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.