BRSK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5112309-Each-of-1 | In Stock | ₹ 42,853.50 |
PIPA5112309 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,853.50
GST (18%): ₹ 7,713.63
Total Price: ₹ 50,567.13
Antigen
BRSK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Brsk1
Gene Alias
BR serine/threonine kinase 1; BR serine/threonine-protein kinase 1; Brain-selective kinase 1; brain-specific serine/threonine-protein kinase 1; Brsk1; Gm1100; hSAD1; KIAA1811; protein kinase SAD1A; RGD1563268; SAD1; SAD1 homolog; SAD1 kinase; SAD1A; SADB; SAD-B; SadB kinase short isoform; serine/threonine kinase SADB; serine/threonine kinase SAD-B; serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
84446
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.
Q8TDC3
Gene Symbols
Brsk1
Immunogen
E. coli-derived Human BRSK1 fragment
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- BRSK1 (SAD1) is a serine/threonine kinase, and is a UV-induced DNA damage checkpoint kinase
- BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes
- Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest
- Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function
- More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization
- While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth
- Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites
- These neurites also displayed both axonal and dendritic markers
- At least two isoforms of BRSK1 are known to exist.