HLA-DRB4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5112826-Each-of-1 | In Stock | ₹ 43,120.50 |
PIPA5112826 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,120.50
GST (18%): ₹ 7,761.69
Total Price: ₹ 50,882.19
Antigen
HLA-DRB4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HLA-DRB4
Gene Alias
DR4; DR-4; DRB1 transplantation antigen; DRB4; HLA class II histocompatibility antigen, DR beta 4 chain; HLA-DR4B; HLA-DRB4; human leucocyte antigen DRB4; leukocyte antigen; major histocompatibility complex, class II, DR beta 4; MHC class II antigen DRB4; MHC class II antigen HLA-DR-beta; MHC class2 antigen; MHC HLA DR-beta chain
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3126
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.
P13762
Gene Symbols
HLA-DRB4
Immunogen
Recombinant Human HLA class II histocompatibility antigen, DR beta 4 chain protein (30-227AA)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- HLA-DRB4 belongs to the HLA class II beta chain paralogues
- This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane
- It plays a central role in the immune system by presenting peptides derived from extracellular proteins
- Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
- The beta chain is approximately 26-28 kDa and its gene contains 6 exons
- Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail
- Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities
- Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation
- DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5
- The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted
- There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.