PIPA5113036
Lass6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5113036-Each-of-1 | In Stock | ₹ 42,497.50 |
PIPA5113036 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,497.50
GST (18%): ₹ 7,649.55
Total Price: ₹ 50,147.05
Antigen
Lass6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CERS6
Gene Alias
4732462C07Rik; AW544719; Ceramide synthase 6; CERS5; CerS6; LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; LASS6; longevity assurance homolog 6; MGC129949; MGC129950; RGD1561599; T1L
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
253782
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration
3.195 mg/mL
Formulation
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.
Q6ZMG9
Gene Symbols
CERS6
Immunogen
Recombinant Human Ceramide synthase 6 protein (324-392AA)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family
- Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis
- However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation
- May be involved in sphingolipid synthesis or its regulation
- Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1
- Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane
- Glycosylation on Asn-18 is not necessary for function
- Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain
- Lass6 displays highest homology to LASS5
- The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb
- Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved
- LASS6 was shown to be broadly expressed in a wide range of tissues
- Recent data suggested a role in cancer differentiation and early embryonic development.