PIPA5113856
Lass6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5113856-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5113856 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Lass6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CERS6
Gene Alias
4732462C07Rik; AW544719; Ceramide synthase 6; CERS5; CerS6; LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; LASS6; longevity assurance homolog 6; MGC129949; MGC129950; RGD1561599; T1L
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
253782
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.
Q6ZMG9
Gene Symbols
CERS6
Immunogen
Synthetic peptide directed towards the N terminal region of human LASS6
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MAGILAWFWN ERFWLPHNVT WADLKNTEEA TFPQAEDLYL AFPLAFCIFM For short term use, store at 2-8°C up to 1 week
- For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles
- Predicted homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 79% Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family
- Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis
- However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation
- May be involved in sphingolipid synthesis or its regulation
- Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1
- Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane
- Glycosylation on Asn-18 is not necessary for function
- Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain
- Lass6 displays highest homology to LASS5
- The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb
- Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved
- LASS6 was shown to be broadly expressed in a wide range of tissues
- Recent data suggested a role in cancer differentiation and early embryonic development.