Phospho-ABL1/ABL2 (Tyr393, Tyr439) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114547-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114547 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-ABL1/ABL2 (Tyr393, Tyr439)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ABL2
Gene Alias
AA536808; Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abelson murine leukemia viral (v-abl) oncogene homolog 2; abelson murine leukemia viral oncogene homolog 1; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 1; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl; ABL proto-oncogene 1, non-receptor tyrosine kinase; ABL proto-oncogene 2, non-receptor tyrosine kinase; ABL1; Abl1-related gene product; abl2; ABLL; AI325092; Arg; arg tyrosine kinase; bcr/abl; bcr/c-abl oncogene protein; c-Abl; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; c-ABL1; E430008G22Rik; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine kinase ARG; tyrosine-protein kinase ABL1; Tyrosine-protein kinase ABL2; tyrosine-protein kinase ARG; v-abl; v-abl Abelson murine leukemia oncogene 1; v-abl
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11350, 11352, 25, 27, 304883, 311860
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
P00519, P00520, P42684, Q4JIM5
Gene Symbols
ABL1, ABL2
Immunogen
A synthesized peptide derived from human ABL1(Accession P00519), corresponding to amino acid residues around phosphorylated Tyr393.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of ABL1/2 only when phosphorylated at Tyr393, which site historically referenced asTyr412
- The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV)
- The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain
- The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL
- In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome
- The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.