Phospho-TPL2 (Ser443) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114600-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114600 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-TPL2 (Ser443)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MAP3K8
Gene Alias
augmented in rheumatoid arthritis 2; AURA2; Cancer Osaka thyroid oncogene; cancer Osaka thyroid, oncogene; CCOT; c-COT; COT; cot (cancer Osaka thyroid) oncogene; COT proto-oncogene serine/threonine-protein kinase; Cot/Tpl2; D17TPL2; EC 1.14.16.2; Est; Estf; Ewing sarcoma transformant; FLJ10486; M3K8; MAP3K 8; Map3k8; MEKK8; mitogen activated protein kinase kinase kinase 8; mitogen-activated protein kinase kinase kinase 8; Protein kinase cot; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; serine/threonine kinase (Tpl-2); serine/threonine-protein kinase cot; TH isoform 3; TH isoform a; TH-4; TPL 2; Tpl2; TPL-2; Tumor progression locus 2; TY3H; TYH
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
116596, 1326, 26410
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
P41279, Q07174, Q63562
Gene Symbols
MAP3K8
Immunogen
A synthesized peptide derived from human MAP3K8/COT around the phosphorylation site of Ser443.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of MAP3K8/COT only when phosphorylated at Ser443
- MAP3K8 (COT) is a serine/threonine kinase which can activate both the MAP and JNK kinase pathways and plays a role in the cell cycle
- Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase (MAPKKK or MEKK)
- MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK
- The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells
- MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105
- This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines
- The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle
- The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.