Phospho-HGS (Tyr216) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114579-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114579 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-HGS (Tyr216)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HGS
Gene Alias
hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; HGNC:4897; Hgr; Hgs; Hrs; Hrs2; human growth factor-regulated tyrosine kinase substrate; protein pp110; SNAP-25-interacting protein Hrs-2; ZFYVE8
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15239, 56084, 9146
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
O14964, Q99LI8, Q9JJ50
Gene Symbols
HGS
Immunogen
A synthesized peptide derived from human HGS around the phosphorylation site of Tyr216.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of HGS only when phosphorylated at Tyr216
- HGS is involved in intracellular signal transduction mediated by cytokines and growth factors
- When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF
- It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin
- HGS may concentrate ubiquitinated receptors within clathrin-coated regions
- It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM
- This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes
- HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.