PIPA5114628
Phospho-PYGL (Ser15) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114628-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114628 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-PYGL (Ser15)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PYGL
Gene Alias
glycogen liver; Glycogen phosphorylase, liver form; GPLL; GSD6; Lgp; liver glycogen phosphorylase; phosphorylase, glycogen, liver; PYGL
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
110095, 5836, 64035
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
P06737, P09811, Q9ET01
Gene Symbols
PYGL
Immunogen
A synthesized peptide derived from human PYGL(Accession P06737), corresponding to amino acid residues around phosphorylated Ser17.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of PYGL only when phosphorylated at Ser15
- This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores
- This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15
- Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls
- Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively
- The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues
- In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly
- Alternative splicing results in multiple transcript variants encoding different isoforms.