DDB2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114728-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114728 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DDB2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DDB2
Gene Alias
2610043A19Rik; damage specific DNA binding protein 2; damage-specific DNA binding protein 2, 48kDa; damage-specific DNA-binding protein 2; DDB p48 subunit; DDB2; DDBb; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
107986, 1643
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
Q92466, Q99J79
Gene Symbols
DDB2
Immunogen
A synthesized peptide derived from human DDB2(Accession Q92466), corresponding to amino acid residues T338-D388.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total DDB2
- Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively
- The DDB heterodimer is involved in repairing DNA damaged by μgtraviolet light
- Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs)
- Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair
- XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities
- The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.