MTSS1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116535-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116535 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MTSS1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MTSS1
Gene Alias
2310003N14Rik; actin monomer-binding protein; BC024131; D130001D01Rik; hypothetical protein; KIAA0429; metastasis suppressor 1; metastasis suppressor protein 1; Metastasis suppressor YGL-1; Mim; MIMA; MIMB; missing in metastasis protein; mKIAA0429; MTSS I-BAR domain containing 1; MTSS1; MTSS1, I-BAR domain containing; Protein MTSS 1; protein MTSS 1; metastasis suppressor protein 1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
211401, 362918, 9788
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.88 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
O43312, Q8R1S4
Gene Symbols
MTSS1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_0555663)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HeLa, HT-29, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver Immunogen sequence: LPAPPDGPEE RGEHSPESPS VGEGPQGVTS MPSSMWSGQA SVNPPLPGPK PSIPEEHRQA IPESEAEDQE REPPSATVSP GQIPESDPAD LSPRDTPQGE D Metastasis suppressor protein 1 (MTSS1) [MIM, "emissing in metastasis"e], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells
- MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function
- It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites
- It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament
- The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization
- Recently, MIM was found to interact with cortactin via SH3 domains
- In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization
- It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells
- MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.