PD-1 (CD279) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116540-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116540 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PD-1 (CD279)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Pdcd1
Gene Alias
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5133
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
2.44 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q15116
Gene Symbols
Pdcd1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 205-259 of human PD-1/CD279 (NP_0050092)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Raji, Mouse spleen, Mouse thymus, Rat thymus Immunogen sequence: TGQPLKEDPS AVPVFSVDYG ELDFQWREKT PEPPVPCVPE QTEYATIVFP SGMGT Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC)
- T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC
- PD-1 can bind two different but related ligands, PDL-1 and PDL-2
- Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "edanger signals"e such as LPS or other molecules associated with bacteria or other pathogens
- Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases
- Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.