PIPA5116681
PON3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116681-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116681 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PON3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PON3
Gene Alias
2810004E20; AI786302; arylesterase 3; lactonase/esterase; paraoxanase-3; paraoxonase 3; PON3; Serum paraoxonase/lactonase 3
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5446
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.07 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q15166
Gene Symbols
PON3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_0009311)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Jurkat, HepG2 Immunogen sequence: HDNWDLTQLK VIQLGTLVDN LTVDPATGDI LAGCHPNPMK LLNYNPEDPP GSEVLRIQNV LSEKPRVSTV YANNGSVLQG TSVASVYHGK ILIGTVFHKT L Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase that is tightly associated with apoA-I in HDL
- PON1 prevents the oxidation of LDL, thereby the formation of atherogenic oxidised-LDL
- Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease
- PON1 activity is lower in subjects prone to development of atherosclerosis such as in type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, indicating the involvement of PON1 in atherosclerosis development
- PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage
- PON3 is similar to PON1 in activity but differs from it in substrate specificity
- PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis
- Human PON3 protein shares the 3 conserved cysteine residues identified in PON1, suggesting their importance of in vivo activities
- PON1-based catalytic scavengers can be a way to safe and effective organophosphate intoxication.