Factor XII Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116703-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116703 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Factor XII
Classification
Polyclonal
Conjugate
Unconjugated
Gene
F12
Gene Alias
beta-factor XIIa part 1; Beta-factor XIIa part 2; coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; F13; Factor 12; factor XII; Factor12; FXII; HAE3; HAEX; HAF; hageman factor
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2161, 306761, 58992
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.43 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
D3ZTE0, P00748, Q80YC5
Gene Symbols
F12
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 336-615 of human F12 (NP_0004962)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HepG2, MCF7, Mouse liver Immunogen sequence: QTPGALPAKR EQPPSLTRNG PLSCGQRLRK SLSSMTRVVG GLVALRGAHP YIAALYWGHS FCAGSLIAPC WVLTAAHCLQ DRPAPEDLTV VLGQERRNHS CEPCQTLAVR SYRLHEAFSP VSYQHDLALL RLQEDADGSC ALLSPYVQPV CLPSGAARPS ETTLCQVAGW GHQFEGAEEY ASFLQEAQVP FLSLERCSAP DVHGSSILPG MLCAGFLEGG TDACQGDSGG PLVCEDQAAE RRLTLQGIIS WGSGCGDRNK PGVYTDVAYY LAWIREHTVS This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain
- The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain
- On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain
- Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa
- The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin
- It activates coagulation factors VII and XI
- Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.