Gemin 5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116720-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116720 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Gemin 5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GEMIN5
Gene Alias
AA407055; AA407208; AI451603; BB194447; C330013N08; gem (nuclear organelle) associated protein 5; gem nuclear organelle associated protein 5; gem-associated protein 5; Gemin5; GEMIN-5
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
216766, 25929, 691231
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.92 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q8BX17, Q8TEQ6
Gene Symbols
GEMIN5
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_0562802)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HeLa Immunogen sequence: RTPVKLESID GNEEESMKEN SGPVENGVSD QEGEEQAREP ELPCGLAPAV SREPVICTPV SSGFEKSKVT INNKVILLKK EPPKEKPETL IKKRKARSLL PLSTSLDHRS KEELHQDCLV LATAKHSREL NEDVSADVEE RFHLGLFTDR ATLYRMIDIE GKGHLENGHP ELFHQLMLWK GDLKGVLQTA AERGELTDNL V The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome
- Thereby, plays an important role in the splicing of cellular pre-mRNAs
- Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP
- In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP
- Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus
- GEMIN5 acts as the snRNA-binding protein of the SMN complex.