PDE12 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116741-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116741 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PDE12
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDE12
Gene Alias
2',5'-phosphodiesterase 12; 2',5'-phosphodiesterase 12-like protein; 2'-PDE; 2-PDE; 2'-phosphodiesterase; E430028B21Rik; fc58c05; fi42f03; LOC558284 protein; LOW QUALITY PROTEIN: 2',5'-phosphodiesterase 12; LRRGT00074; Mitochondrial deadenylase; PDE12; phosphodiesterase 12; RGD1310975; wu:fc58c05; wu:fi42f03; zgc:136374
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
211948, 306231
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.3 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q3TIU4, Q6AXQ5
Gene Symbols
PDE12
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_0013091061)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Mouse thymus, Rat thymus Immunogen sequence: AVEKLSRAEA GSQTAAGAME RAVVRCVPSE PKLSLSFALA DGSHKNMQRD QSEPLGRVLS RIATNALKGH AKAAAAKKSR KSRPNASGGA ACSGPGPEPA VFCEPVVKLY YREEAVAEDV LNVDAWQDGA VLQIGDVKYK VERNPPAFTE LQLPRYIMAG FPVCPKLSLE FGDPASSLFR WYKEAKPGAA EPEVGVPSSL SPSSPSSSWT ETDVEERVYT PSNADIGLRL KLHCTPGDGQ RFGHSRELES VCVVEAGPGT CTFDHRHLYT KKVTEDALIR TVSY PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system
- This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP
- It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs)
- Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.