EXT1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116952-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5116952 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
EXT1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
EXT1
Gene Alias
AA409028; exostoses (multiple) 1; exostosin 1; exostosin glycosyltransferase 1; exostosin-1; EXT; Ext1; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Langer-Giedion syndrome chromosome region; LGCR; LGS; multiple exostoses protein 1; Multiple exostoses protein 1 homolog; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; putative tumor suppressor protein EXT1; TRPS2; TTV
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14042, 2131, 299907
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.06 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P97464, Q16394
Gene Symbols
EXT1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 467-746 of human EXT1 (NP_0001182)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: K-562, SW480, PC-3, Mouse liver, Mouse lung Immunogen sequence: YYYANLGLKP PSKFTAVIHA VTPLVSQSQP VLKLLVAAAK SQYCAQIIVL WNCDKPLPAK HRWPATAVPV VVIEGESKVM SSRFLPYDNI ITDAVLSLDE DTVLSTTEVD FAFTVWQSFP ERIVGYPARS HFWDNSKERW GYTSKWTNDY SMVLTGAAIY HKYYHYLYSH YLPASLKNMV DQLANCEDIL MNFLVSAVTK LPPIKVTQKK QYKETMMGQT SRASRWADPD HFAQRQSCMN TFASWFGYMP LIHSQMRLDP VLFKDQVSIL RKKYRDIERL Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the formation of exostoses (EXT), which are cartilage-capped bony protuberances mainly located on long bones
- Two proteins associated with EXT, EXT1 and EXT2, form homo/heteromeric complexes in vivo, which leads to the accumulation of both proteins in the Golgi apparatus
- EXT1 and EXT2 are endoplasmic reticulum-localized type II transmembrane glycoproteins that possess, or are tightly associated with, glycosyltransferase activities involved in the polymerization of the glycosaminoglycan, heparan sulfate (HS)
- EXT2 is a protein that harbors the D-glucuronyl (GlcA) and N-acetyl-D-glucosaminyl (GlcNAc) transferase activities required for biosynthesis of HS
- EXT1 rescues defective HS biosynthesis and elevates low GlcA and GlcNAc transferase levels in mutated cells.