KMT2E Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117037-Each-of-1 | In Stock | ₹ 45,434.50 |
PIPA5117037 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,434.50
GST (18%): ₹ 8,178.21
Total Price: ₹ 53,612.71
Antigen
KMT2E
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KMT2E
Gene Alias
1810033J14Rik; 9530077A04Rik; D230038D11Rik; HDCMC04P; histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; Inactive histone-lysine N-methyltransferase 2E; Inactive lysine N-methyltransferase 2E; KMT2E; lysine (K)-specific methyltransferase 2E; lysine methyltransferase 2E; lysine N-methyltransferase 2E; MGC70452; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia protein 5; Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog; NKp44L
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
311968, 55904, 69188
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.61 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
Q3UG20, Q8IZD2
Gene Symbols
KMT2E
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human MLL5 (NP_0611523)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: NCI-H460, 293T, Mouse brain Immunogen sequence: VELYTAFQHT PTSITLTASR VSKVNDKRRK KSGEKEQHIS KCKKAFREGS RKSSRVKGSA PEIDPSSDGS NFGWETKIKA WMDRYEEANN NQYSEGVQRE AQRIALRLGN GNDKKEMNKS DLNTNNLLFK PPVESHIQKN KKILKSAKDL PPDALIIEYR GKFMLREQFE ANGYFFKRPY PFVLFYSKFH GLEMCVDART FGNEARFIRR SCTPNAEVRH EIQDGTIHLY IYSIHSIPKG TEITIAFDFD YGNCKYKVDC ACLKENPECP VLKRSSESME NINSGYETRR KKGKKDKDIS K The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family
- The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias
- MLL2, also designated ALR, exists within a complex of proteins
- MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival
- The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors
- MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes
- MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders
- MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus
- MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression
- The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.