HERC5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117319-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5117319 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
HERC5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HERC5
Gene Alias
CEB1; CEBP1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; HERC5; probable E3 ubiquitin-protein ligase HERC5
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51191
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.98 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
Q9UII4
Gene Symbols
HERC5
Immunogen
Recombinant protein encompassing a sequence within the center region of human HERC5. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Centrifuge briefly prior to opening
- HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation
- It acts a positive regulator of innate antiviral response in cells induced by interferon
- HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner
- It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse
- HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.