CrkRS Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117328-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5117328 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CrkRS
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDK12
Gene Alias
1810022J16Rik; AI646528; CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cdk12; Cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; Crkrs; cyclin dependent kinase 12; cyclin-dependent kinase 12; cyclin-dependent kinase 12 isoform; D11Ertd752e; H KIAA0904; hCDK12; Kiaa0904; Pksc; Protein kinase for splicing component
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51755, 69131
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.83 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
Q14AX6, Q9NYV4
Gene Symbols
CDK12
Immunogen
Human CrkRS
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
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Description
- Centrifuge briefly prior to opening
- Plays important functions in early cell signaling
- Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters
- Activator of the NF-ELAM1/delta-A site of the E-selectin promoter
- Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers
- Also can bind TRE promoter sequences when heterodimerized with members of the JUN family
- Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
- Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities
- It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.