CREB Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117891-Each-of-1 | In Stock | ₹ 39,427.00 |
PIPA5117891 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,427.00
GST (18%): ₹ 7,096.86
Total Price: ₹ 46,523.86
Antigen
CREB
Classification
Polyclonal
Formulation
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.
P16220
Gene Symbols
CREB1
Immunogen
E. coli-derived Human CREB fragment
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
CREB1
Gene Alias
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1385
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Related Products
Description
- CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors
- Activation of CREB is dependent upon the phosphorylation of serine 133
- Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1
- Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor
- CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133
- CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory
- In humans, the gene is located on the q arm of chromosome 2
- Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.