PRKAR1A Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5118191-Each-of-1 | In Stock | ₹ 39,427.00 |
PIPA5118191 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,427.00
GST (18%): ₹ 7,096.86
Total Price: ₹ 46,523.86
Antigen
PRKAR1A
Classification
Polyclonal
Formulation
PBS with 0.03% ProClin 300; pH 7
Gene Accession No.
P10644
Gene Symbols
PRKAR1A
Immunogen
E. coli-derived Human PRKAR1A fragment
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
PRKAR1A
Gene Alias
1300018C22Rik; ACRDYS1; ADOHR; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; CAR; Carney complex type 1; CNC; CNC1; PKR1; PPNAD1; PRKAR1; Prkar1a; protein kinase A type 1a regulatory subunit; protein kinase cAMP-dependent type I regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type 1, alpha; protein kinase, cAMP dependent regulatory, type I, alpha; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; RIalpha; RIIA; Tissue-specific extinguisher 1; Tse1; Tse-1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5573
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
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Description
- cAMP is a signaling molecule important for a variety of cellular functions
- cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins
- The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits
- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits
- Four different regulatory subunits and three catalytic subunits have been identified in humans
- This gene encodes one of the regulatory subunits
- This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids
- Mutations in this gene cause Carney complex (CNC)
- This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2
- A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40)
- Three alternatively spliced transcript variants encoding the same protein have been observed.