Aquaporin 0 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5120840-Each-of-1 | In Stock | ₹ 44,811.50 |
PIPA5120840 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,811.50
GST (18%): ₹ 8,066.07
Total Price: ₹ 52,877.57
Antigen
Aquaporin 0
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MIP
Gene Alias
AQP0; aquaporin 0; Aquaporin0; aquaporin-0; Cat; CTRCT15; dominant cataract; Hfi; hydropic fibers; lens fiber major intrinsic protein; lens opacity; LIM1; Lop; major intrinsic protein of eye lens fiber; major intrinsic protein of lens fiber; MIP; MIP26; MP26; Palm; shrivelled; Svl
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17339, 25480, 4284
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.83 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P09011, P30301, P51180
Gene Symbols
MIP
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MIP (NP_036196.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive test controls include: HepG2, U-251MG, Mouse skeletal muscle, Mouse heart, Mouse liver, Mouse testis, Mouse eye, Rat eye
- The target is usually found in the following locations: Cell junction, Cell membrane, Multi-pass membrane protein, gap junction
- Immunogen sequence: LALATLVQSV GHISGAHVNP AVTFAFLVGS QMSLLRAFCY MAAQLLGAVA GAAVLYSVTP PAVRGNLALN TLHPAVSVGQ ATTVEIFLTL QFVLCIFATY D AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization
- AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating
- The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other
- The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms
- These truncation sites may be involved in the development of cataracts.